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Pomegranate: This fruit is rich in ellagic acid, which has been shown to inhibit prostate cancer cell proliferation as well as induce apoptosis (cell death) (ref). In laboratory studies, using breast cancer cell lines, it has also been shown to reduce cell migration associated with metastasis (Ref)
Green tea: This tea is rich EGCG (epigallocatechin gallate), a chemical that concentrates in prostatic tissue. The EGCG blocks another chemical, ornithine decarboxylase, that enables cells to bypass apoptosis (Ref). Green tea has also been shown to inhibit breast and prostate cancer proliferation (Ref)
Turmeric: This spice gets its characteristic yellow colour from a natural chemical called curcumin. Curcumin has been shown to inhibit prostate cancer cell growth as well as increasing apoptosis (Ref). Furthermore, it has anti-inflammatory properties (Ref) and is associated with inhibition of cells that lead to breast cancer (Ref)
Broccoli: This vegetable has been shown to have chemicals that inhibit growth and promote apoptosis of cancer cells (Ref). Regular consumption of broccoli is associated with down-regulation of genes linked to cancer as well as up-regulation of genes linked to cancer suppression (Ref)
References
Barber NJ, et al. Lycopene inhibits DNA synthesis in prostate cells in vitro and is associated with a reduced PSA velocity in a phase II clinical study. Prostate Cancer Prostatic Dis ( 2006).9(4): 407-13.
Gasper AV et al The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a model of prostate cancer. Molecular Cancer 2010, 9:189
Gasper AV et al (2005) Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli. Am J Clin Nutr 82: 1283–1291.
Handler N, Jaeger W, Puschacher H, Leissser K, Erker T. Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 inhibitors. Chem Pharm Bull. 2007 55(1): 64-71
Heinen MM, Hughes MC, Ibiebele TI, Marks GC, Green CM, van der Pols. Intake of antioxidant nutrients and the risk of skin cancer (2007) EJC 43; (18) pp 2707-16.
Joseph MA, et al Cruciferous vegetables, genetic polymorphisms and prostate cancer risk. Nutr Cancer. 2004;50(2):206-213.
Kakarla M, et al (2010). Targeting breast stem cells with the preventive compounds curcumin and piperine Breast Cancer Res treatments 122(3):777-785.
Khan N and Mukhtar H. Pomegranate inhibits growth of primary lung tumors in mice. Cancer Res 2007;67:3475-82. (doi: 10.1358/dof.2007.032.06.1097137).
Lansky EP et al Possible synergistic prostate cancer suppression by anatomically discrete megranate fractions. Invest New Drugs. 2005;23:11–20.
Liao J, yang GY, Park ES (2004). Inhibition of lung carcinogenesis and effects on angiogenesis and apoptosis in mice given green tea. Nutr Cancer, 48 (1), pp.44-53
Malik A, et al. Pomegranate fruit juice for chemo-prevention and chemotherapy of prostate cancer. Proc Natl Acad Sci USA. 2005;102:14813–14818.
McLarty J Tea Polyphenols – biochemical mode of action (2009). Cancer Prev Res: 1940-6207.CAPR-08-0167.
Porrini M and Riso P. Factors influencing the bioavailability of antioxidants in foods: a critical appraisal. Nutr Metab Cardiovas. 2008:80(4):353-61.
Rettig MB, et al. Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-κβ-dependent mechanism. Mol Cancer Ther. 2008;7:2662–2671
Rock CL, et al Carotenoids and Recurrence-Free Survival in Women With a History of Breast Cancer (2005) J Clin Oncol; 23(27):6631-8.
Schröder FH, et al Randomized, double-blind, placebo-controlled crossover study in men with prostate cancer and rising PSA: effectiveness of a dietary supplement. Eur Urol 2005 48(6):922-30.
Shah BH, et al (1999). Inhibitory effect of curcumin, on platelet-activating factor through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol., 58(7): 1167–1172.
Steward W and Gescher AJ Curcumin in cancer management: Recent results of analogue design, clinical studies and desirable future research Molecular Nutrition & Food Research, 52 (9) 1005-9.
Sun CL, Yuan JM, Koh WP, Lee HP, Yu MC, Green tea and cancer risk: The Singapore Chinese Health Study (2007). Carcinogenesis; 28(10):2143-48 (do
Wang L, et al. Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells. Integr Biol (Camb) 2011;3:742–754
Yang CS, Maliakal P, Meng X. Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol. 2002;42:25-54.
Zhang HN, Yu CX, Chen WW, Young CY (2007), Curcumin down regulates gene NKX3.1 in prostate cancer cell lines (LNcaP) (2007). Acta Pharmacologica
Green tea: This tea is rich EGCG (epigallocatechin gallate), a chemical that concentrates in prostatic tissue. The EGCG blocks another chemical, ornithine decarboxylase, that enables cells to bypass apoptosis (Ref). Green tea has also been shown to inhibit breast and prostate cancer proliferation (Ref)
Turmeric: This spice gets its characteristic yellow colour from a natural chemical called curcumin. Curcumin has been shown to inhibit prostate cancer cell growth as well as increasing apoptosis (Ref). Furthermore, it has anti-inflammatory properties (Ref) and is associated with inhibition of cells that lead to breast cancer (Ref)
Broccoli: This vegetable has been shown to have chemicals that inhibit growth and promote apoptosis of cancer cells (Ref). Regular consumption of broccoli is associated with down-regulation of genes linked to cancer as well as up-regulation of genes linked to cancer suppression (Ref)
References
Barber NJ, et al. Lycopene inhibits DNA synthesis in prostate cells in vitro and is associated with a reduced PSA velocity in a phase II clinical study. Prostate Cancer Prostatic Dis ( 2006).9(4): 407-13.
Gasper AV et al The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a model of prostate cancer. Molecular Cancer 2010, 9:189
Gasper AV et al (2005) Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli. Am J Clin Nutr 82: 1283–1291.
Handler N, Jaeger W, Puschacher H, Leissser K, Erker T. Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 inhibitors. Chem Pharm Bull. 2007 55(1): 64-71
Heinen MM, Hughes MC, Ibiebele TI, Marks GC, Green CM, van der Pols. Intake of antioxidant nutrients and the risk of skin cancer (2007) EJC 43; (18) pp 2707-16.
Joseph MA, et al Cruciferous vegetables, genetic polymorphisms and prostate cancer risk. Nutr Cancer. 2004;50(2):206-213.
Kakarla M, et al (2010). Targeting breast stem cells with the preventive compounds curcumin and piperine Breast Cancer Res treatments 122(3):777-785.
Khan N and Mukhtar H. Pomegranate inhibits growth of primary lung tumors in mice. Cancer Res 2007;67:3475-82. (doi: 10.1358/dof.2007.032.06.1097137).
Lansky EP et al Possible synergistic prostate cancer suppression by anatomically discrete megranate fractions. Invest New Drugs. 2005;23:11–20.
Liao J, yang GY, Park ES (2004). Inhibition of lung carcinogenesis and effects on angiogenesis and apoptosis in mice given green tea. Nutr Cancer, 48 (1), pp.44-53
Malik A, et al. Pomegranate fruit juice for chemo-prevention and chemotherapy of prostate cancer. Proc Natl Acad Sci USA. 2005;102:14813–14818.
McLarty J Tea Polyphenols – biochemical mode of action (2009). Cancer Prev Res: 1940-6207.CAPR-08-0167.
Porrini M and Riso P. Factors influencing the bioavailability of antioxidants in foods: a critical appraisal. Nutr Metab Cardiovas. 2008:80(4):353-61.
Rettig MB, et al. Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-κβ-dependent mechanism. Mol Cancer Ther. 2008;7:2662–2671
Rock CL, et al Carotenoids and Recurrence-Free Survival in Women With a History of Breast Cancer (2005) J Clin Oncol; 23(27):6631-8.
Schröder FH, et al Randomized, double-blind, placebo-controlled crossover study in men with prostate cancer and rising PSA: effectiveness of a dietary supplement. Eur Urol 2005 48(6):922-30.
Shah BH, et al (1999). Inhibitory effect of curcumin, on platelet-activating factor through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol., 58(7): 1167–1172.
Steward W and Gescher AJ Curcumin in cancer management: Recent results of analogue design, clinical studies and desirable future research Molecular Nutrition & Food Research, 52 (9) 1005-9.
Sun CL, Yuan JM, Koh WP, Lee HP, Yu MC, Green tea and cancer risk: The Singapore Chinese Health Study (2007). Carcinogenesis; 28(10):2143-48 (do
Wang L, et al. Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells. Integr Biol (Camb) 2011;3:742–754
Yang CS, Maliakal P, Meng X. Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol. 2002;42:25-54.
Zhang HN, Yu CX, Chen WW, Young CY (2007), Curcumin down regulates gene NKX3.1 in prostate cancer cell lines (LNcaP) (2007). Acta Pharmacologica